PAD-Beads enrichment enhances detection of PrPSc using real-time quaking-induced conversion
Abstract Objective Scrapie is a transmissible spongiform encephalopathy (TSE) that naturally occurs in sheep and goats.This fatal neurodegenerative disease results from misfolding Nail Forms of the normal cellular prion protein (PrPC) to a pathogenic prion protein form (PrPSc).This pathogenic form, PrPSc, accumulates in the brain and lymphoid tissu